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Stat5 is a therapeutic target protein for advanced prostate CANCER
Published 2008-04-13
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Researchers at Jefferson's Kimmel Cancer Center in Philadelphia have shown that they can effectively kill prostate cancer cells in both the laboratory and in experimental animal models by blocking a signaling protein that is key to the cancer's growth. The work proves that the protein, Stat5, is both vital to prostate cancer cell maintenance and that it is a viable target for drug therapy.
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The Risk For Prostate CANCER predicted by a set of genetic variations
Published 2008-04-13
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Researchers report that a set of genetic variations in at least four regions of DNA strongly predicts prostate cancer risk and that these variations may be responsible for a large number of prostate cancer cases in white men in the United States. The research was conducted by investigators from the National Cancer Institute (NCI), part of the National Institutes of Health, and their partners in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. CGEMS researchers are scanning the entire human genome to identify common, inherited gene variations that increase the risks for breast and prostate cancers.
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Vitamin supplements do not protect against lung CANCER, study says
Published 2008-04-13
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Vitamin supplements do not protect against lung cancer, according to a study of more than 77,000 vitamin users. In fact, some supplements may even increase the risk of developing it.
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Prostate CANCER Spread Predicted by New Blood Marker
Published 2008-04-12
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Researchers report finding a new blood biomarker that enables close to 98 percent accuracy in predicting the spread of prostate cancer to regional lymph nodes.
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Women are more severely distressed than men When Couples Face CANCER Diagnosis
Published 2008-04-12
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In a couple where one of the partners is diagnosed with cancer, women are more consistently and severely distressed than men, regardless of whether they are the person with the disease or the healthy partner. The results of a research paper appearing in the Psychological Bulletin report that when a couple is faced with coping with a diagnosis of cancer, gender plays a greater role than who the patient is.
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New function for CANCER-related protein may help Alzheimer’s disease pathology
Published 2008-04-12
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The cancer-related protein Akt may profoundly influence the fate of the tau protein, which forms bundles of tangled nerve cell fibers in the brain associated with Alzheimer’s disease, reports a new study led by researchers at the University of South Florida and the Mayo Clinic in Jacksonville, FL.
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AKT family of proteins is crucial to survival in both CANCERous and non-CANCERous cells
Published 2008-04-12
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A gene crucial for embryonic development can quickly become a potent cancer promoter in adult mice after a genetic misalignment, according to researchers from Fox Chase Cancer Center, causing white blood cells to become cancerous spontaneously.
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The key to prevent CANCER's Recurrence is stress reduction
Published 2008-04-12
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A scientist shows that mind may indeed affect matter. After the surgical removal of a malignant tumor, the chance that cancer will re-appear in a different location of the body remains high. But new research from Tel Aviv University, in a bold new field called Psychoneuroimmunology, may prevent those cancer cells from taking root again -- and the key to the treatment is stress reduction.
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Thalidomide provide more hope to women diagnosed with Ovarian CANCER
Published 2008-04-12
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Thalidomide, a drug blamed in the 1950s for causing birth defects, is now showing promise as a safe and effective treatment for women with recurrent ovarian cancer, according to a study led by a University of Minnesota Cancer Center researcher.
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Highly targeted therapies Against Hormone-dependent Breast CANCER
Published 2008-04-12
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The identification of two cellular receptors that likely contribute to the genesis of hormone-dependent breast cancer points the way to new, highly targeted therapies against the disease, says a team led by scientists at Weill Cornell Medical College in New York City. The finding also helps explain how daily use of medicines such as aspirin might help keep these breast tumors at bay.
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Eating cruciferous vegetables is associated with reduced risk for bladder CANCER
Published 2008-04-12
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A concentrated extract of freeze dried broccoli sprouts cut development of bladder tumors in an animal model by more than half, according to a report in the March 1 issue of Cancer Research.
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Family of genes linked to the development of liver CANCER has been identified
Published 2008-04-12
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An interdisciplinary team of researchers at Stony Brook University Medical Center has identified a family of genes linked to the development of liver cancer. Principal Investigator Wadie F. Bahou, M.D., Professor of Medicine and Genetics, and colleagues discovered in a mouse model that the loss of one specific gene (Iqgap2) in this family causes Hepatocellular carcinoma (HCC). They also found that when another member of the gene family (Iqgap1) is turned on, a more aggressive form of the disease occurs.
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Survival From Secondary Brain Tumors Correlated to Breast CANCER Subtypes
Published 2008-04-12
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Screening breast cancers for three receptors could help doctors predict the likely survival of patients with brain metastases. A study published in the open access journal Breast Cancer Research shows that patients with tumours that are negative for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth receptor-2 (HER2) or that are HER2+/ER- appear to be most at risk from developing brain metastases. Survival is also correlated to the triple receptor status.
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HPV DNA-based testing is more effective in detecting preCANCERous changes
Published 2008-04-10
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Adjustment of cervical cancer screening protocols as a woman ages may be cost-effective, regardless of whether she has been vaccinated against the human papillomavirus (HPV) that causes cervical cancer.
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Anti-CANCER "warhead" targets the acidic signature of tumor cells
Published 2008-04-10
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Researchers in California report development of an anti-cancer "warhead" that targets the acidic signature of tumor cells in much the same way that heat-seeking missiles seek and destroy military targets that emit heat. These acid-seeking substances are not toxic to healthy cells, and represent a new class of potentially safer, more effective anti-cancer drugs, they say.
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Human CANCERs Eliminated By cardiac hormones
Published 2008-04-10
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Hormones produced by the heart eliminated human pancreatic cancer in more than three-quarters of the mice treated with the hormones and eliminated human breast cancer in two-thirds of the mice, according to researcher David Vesely, a doctor at the James A. Haley Veterans Hospital in Tampa and a professor at the University of South Florida (USF).
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New Test to Provide Better Care Of Breast CANCER Patients
Published 2008-04-10
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A new test that examines large sections of the sentinel lymph node for genes expressed by breast cancer could reduce the risk of recurrence and multiple surgeries, doctors say.
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Combined hormone therapy may have adverse effect on breast CANCER detection
Published 2008-04-10
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Combined hormone therapy appears to increase the risk that women will have abnormal mammograms and breast biopsies and may decrease the effectiveness of both methods for detecting breast cancer, according to a new report.
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Gap in death rates from breast CANCER between black and white women has increased
Published 2008-04-10
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A new study from the American Cancer Society finds that while breast cancer death rates are decreasing for white women in every U.S. state, for African American women, death rates are either flat or rising in at least half the states. The study finds breast cancer death rates among African American women are decreasing in only 11 of 37 states with sufficient numbers for analysis and in the District of Columbia. In the rest, death rates are either flat (24 states) or actually increasing (two states: Arkansas and Mississippi).
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New mechanism explains Resistance of Ovarian CANCERs To Platinum-based Chemotherapy
Published 2008-04-09
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A team of researchers led by Fred Hutchinson Cancer Research Center has identified a new mechanism that explains why some recurrent ovarian tumors become resistant to treatment with commonly used platinum-based chemotherapy drugs such as cisplatin and carboplatin. They describe their research online Feb. 10 in the journal Nature.
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